The TNF superfamily ligands, BAFF and APRIL, are involved in the pathogenesis of a number of autoimmune diseases by regulating plasma cell survival. AdipoGen Life Sciences provides unique antibodies to study autoimmune diseases in mice by blockade of mouse BAFF or APRIL, such as anti-BAFF (mouse), mAb (blocking) (Sandy-2) or anti-APRIL (mouse), mAb (rec.) (blocking) (Apry-1-1).
In a recent study, Haselmayer et al., tested several inhibitors of BAFF or APRIL in a model of mouse autoimmune disease (SLE) to confirm that inhibition of mouse BAFF and APRIL by the receptor TACI-Fc is more efficient than inhibition of BAFF alone or APRIL alone on long-lived plasma cell survival. To block mouse APRIL in this study, anti-APRIL (mouse), mAb (rec.) (blocking) (Apry-1-1) (AG-27B-0001PF) from Adipogen was injected in C57BL/6 mice.
Myokines – Muscle, Exercise & Obesity
Skeletal muscles secrete cytokines and growth factors, called myokines that can potentially act in an autocrine, a paracrine and/or an endocrine manner to modulate metabolic, inflammatory and other processes. AdipoGen Life Sciences offers a broad range of proteins and small molecules to study the interactions of muscles, exercise and obesity.